Mechanical degrees of freedom of isolated macroscopic objects provide an interesting avenue for observing quantum mechanical effects. To this end, experiments have demonstrated generation of quantum state of mechanical motion, like ground state cooling  and entanglement between microwave fields and mechanical motion . An interesting extension is coupling non-linear (for example two level) systems with mechanical resonators, as this provides a way to generate or detect non-Gaussian states of mechanical motion. Using the same coupling, mechanical degrees of freedom can also be used to affect the internal states (e.g. spin) of emitters. We focus on exploring and utilizing coupling between mechanical degrees of freedom and anharmonic emitters in two systems. First is single or coupled self-assembled quantum dots embedded in micron sized GaAs mechanical resonators, second is few layer Transition Metal Dichalcogenide (TMD) flakes that are suspended.